Fq PK/PD : peak to MIC ratio in the clinic (1/2)

Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. Preston et al., J.A.M.A., 1998 Jan 14;279(2):125-9

OBJECTIVE: To prospectively quantitate the relationship between plasma levels of levofloxacin and successful clinical and/or

microbiological outcomes and occurrence of adverse events in infected patients.

PATIENTS: 313 with clinical signs and symptoms of bacterial infections of the respiratory tract, skin, or urinary tract.

MAIN OUTCOME MEASURES: Clinical response and microbiological eradication of pathogenic organisms.

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