Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...
Inadequate dosing of antibiotics is probably an important reason for misuse and subsequent risk of resistance.
A recommendation on proper dosing regimens for different infections would be an important part of a comprehensive strategy.
The possibility to produce such a dose recommendation based on pharmacokinetic and pharmacodynamic considerations will be further investigated in one of the CPMP working parties…
EMEA discussion paper on Antimicrobial resistance, January 3, 1999 EMEA/9880/99