Main causes of antibiotic failures...
Pharmacokinetics / pharmacodynamics as a step towards an improved therapy...
What does the clinician (and the patient) want ?
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation of Efficacy (1/2)
PK/PD in drug develop-ment A view from FDA
Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...
PK/PD and drug devlop-ment A view from EMEA
Are PK/PD important in resistance ?
Just a few of them…
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation
Pharmacokinetic/ Pharmacodynamics: What are the goals ?
Pharmacokinetic/ Pharmacodynamics
PK/PD and effectiveness: patterns of antimicrobial activity (after WA. Craig, 2000)
PK/PD and effectiveness: role of concentration an example with Listeria monocytogenes
PK/PD and FQ effectiveness: in vitro dynamic models
PK/PD of fluoroquinolones and effectiveness in clinics: role of the 24h-AUC / MIC ratio for ciprofloxacin in hospital-acquired pneumonia
Fluoroquinolones: the role of the peak for efficacy: animal models
Fq PK/PD : peak to MIC ratio in the clinic (1/2)
Fq PK/PD : peak to MIC ratio in the clinic (2/2)
Why would / should PK/PD be important for resistance ?
PK/PD and resistance: importance of the rate of bacterial killing
PK/PD and resistance: importance of the bactericidal rate
PK/PD and resistance: cooperation with host defenses
PK/PD and resistance: subpopulations with reduced susceptibilities
PK/PD and resistance: subpopulations or populations ...
Where would YOU place the breakpoint ?
PK/PD and resistance: acquisition of resistance mechanisms
Resistance to fluoroquinolones: the basics
PK/PD and point mutations ...
PK/PD and point mutation in DNA gyrase...
Peak concentrations as a tool to prevent emergence of resistance : using “ PK / PD acceptable ” MICs and MPCs
PK/PD and antibiotic efflux pumps...
PPT Slide
Antibiotic efflux pumps in eucaryotic cells…
PK/PD for prevention of resistance: clinical data
PK/PD for what ?
And may we have a very bright future...
Email: tulkens@facm.ucl.ac.be
Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm