The design of the SUPERFLOXACIN... Pharmacokinetics / Pharmacodynamics...
- aim for low/slow clearance
? increased 24h-AUC / MIC ratio
2. increase Cmax (? oral absorption, low hepatic metabolism, qD schedule, low prot. binding …);
? increased peak to MIC ratio
3. improve the intrinsic properties of the molecule
- reduce MIC ? increased peak / MIC and AUC / MIC ratios
- reduce MPC ? decrease risk of emergence of resistance