Peak concentrations as a tool to prevent emergence of resistance (MPC): accepting NCCLS breakpoints ...
Drug Dosage Cmax Bkpt expected
(mg/24h) (mg/L) (mg/L) MPC @ Bkpt
norfloxacin 800 2.4 * < 4 * ~ 48
ciprofloxacin 500 2.4 * < 1 * ~ 12
ofloxacin 400 3-4.5 *, + < 2 * ~ 24
levofloxacin 500 5-6 *, + < 2 * ~ 24
moxifloxacin 400 4.5 * < 2 * ~ 7.2
* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, and AVELOX®
+ first dose to equilibrium