Fq PK/PD : peak to MIC ratio in the clinic (2/2)

Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. Preston et al., J.A.M.A., 1998 Jan 14;279(2):125-9

RESULTS:

• 134 / 313 had both PK and MIC

• clinical AND bacterial outcomes were related to peak/MIC (logistic regression; p < 0.001)

• results were favourable if peak / MIC > 12.2

But:

- very few failures (clinical and microbiol. success rates: 95 and 96 %)

- mainly single daily doses (500 mg)  ? always high peak

? peak and AUC are directly linked

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