The role of the peak : animal models

• peak/MIC ratio becomes predictive at ratios > 10; (AUC / MIC is more predictive at peak/MIC < 10) no influence of time > MIC  Drusano et al., Antimicrob Agents Chemother 1993 Mar;37(3):483-90)

• Dose-dependency in vivo  Dalhoff, J Antimicrob Chemother 1999 May;43 Suppl B:51-9)

• Penetration in inflammatory fluids and interstitial fuids,  and rapid equilibration between compartments
  • Wise et al., Antimicrob Agents Chemother 1999 Jun;43(6):1508-10)
  • Muller et al., Antimicrob Agents Chemother 1999 Oct;43(10):2345-9)
  • Stass et al., Antimicrob Agents Chemother 1998 Aug;42(8):2060-5)

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