24h-AUC / MIC as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)
Drug Dosage 24h-AUC acceptable
(mg/24h) (mg/L x h) MIC (pneumonia)
norfloxacin 800 14 *, # 0.1
ciprofloxacin 500 12 * 0.1
ofloxacin 400 31 to 66 *, + 0.2 - 0.4
levofloxacin 500 47 * 0.4
moxifloxacin 400 48 * 0.4
* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, and AVELOX®
+ first dose to equilibrium