PK/PD of FQ: in vitro dynamic models

• Antibacterial effect is correlated with drug exposure (AUC / MIC); AUC / MIC is best predictor in inter-fluoroquinolones comparisons;  minor influence of the inoculum size;
  • Firsov et al., Antimicrob Agents Chemother 1998 Nov;42(11):2841-7
  • Firsov et al., Antimicrob Agents Chemother 1998 Nov;42(11):2848-52
  • Firsov et al., J Antimicrob Chemother 1999 Apr;43(4):483-90
  • Fissov et al., Antimicrob Agents Chemother 1999 Mar;43(3):498-502

• log change in viable counts is related to AUC / MIC ratio  McGowan et al., Antimicrob Agents Chemother 1999 Jul;43(7):1560-4

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