Peak concentrations of the main fluoroquinolones (p.o.)

Drug Dosage Bioav. Cmax

(mg/24h) (%) (mg/L)

norfloxacin 800 ~ 35 2.4 *

ciprofloxacin 500 ~ 70 2.4 *

ofloxacin 400 ~ 95 3-4.5 *, +

levofloxacin 500 ~ 99 5-6 *, +

moxifloxacin 400 ~ 90 4.5 *

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®,

LEVAQUIN®, and AVELOX®

+ first dose to equilibrium

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