?-lactams : how long can you remain above the MIC ...

time concentration MIC

(hours) (for 100 mg/L at t=0h) 16 8 4 2 1

2 50 ok ok ok ok ok

4 25 ok ok ok ok ok

6 12 ! ok ok ok ok

8 6 !! ! ok ok ok

12 3 !!! !! ! ok ok

* half-life of 2h; 1g for an adult of 50kg; Vd = 0.2 l/kg