Table of Contents
PPT Slide
The ideal antibiotic ...
Will it always be ideal ?
Main causes of antibiotic failures... Adapted from
Pechère J.C., 1988, 1993, 1998
Pharmacokinetics / pharmacodynamics as a step towards
therapy...
Pharmacokinetics ...
Pharmacodynamics ...
Pharmacokinetic/ Pharmacodynamics in drug development
and evaluation of efficacy
PK/PD in drug develop-ment A view from FDA
Are PK/PD important for efficacy / toxicity ?
Pharmacokinetic/ Pharmacodynamics and antibiotic
resistance...
Are PK/PD important in resistance ?
Single dose PK/PD parameters: a first sight
Multiple doses: the issues...
Pharmacokinetic / Pharmacodynamic parameters: a
2d sight
Pharmacokinetic/ Pharmacodynamics
PK/PD patterns of antimicrobial activity (1 of
3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (2 of
3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (3 of
3) (after WA. Craig, 2000)
PK/PD: role of concentration Point of Principle
an example with Listeria monocytogenes
Pharmacokinetics / Pharmacodynamics in action ...
Aminoglycosides : obtain a peak !
Aminoglycosides: practical applications for a 30
min infusion
Pharmacokinetics / Pharmacodynamics in action ...
?-lactams : remain above the MIC ...
?-lactams : how long can you remain above the MIC
...
? - lactams* in clinical practice: is 1 g / 50
kg in bolus 2 times per day enough ?
? - lactams* in clinical practice: is 1 g / 50
kg in bolus 2 times per day enough ?
? - lactams* in clinical practice: is 1 g / 50
kg in bolus 2 times per day enough ?
Pharmacokinetics / Pharmacodynamics in action ...
Als u een optimale bescherming met ? lactamen wenst…
Voorstel : continu-infusie (vb. 4 g / dag)
? - lactamen in de praktijk: voorstel : continu-infusie
(4 g / dag)
PK/PD of fluoroquinolones: role of the 24h-AUC
MIC ciprofloxacin in hospital-acquired pneumonia
AUC / MIC ratio
PPT Slide
PPT Slide
PPT Slide
Pharmacokinetics / Pharmacodynamics in action ...
24h-AUC / MIC as a tool to determine acceptable
sensitivities to fluoroquinolones (p.o.)
The role of the peak for Fluoroquinolones ...
Peak concentrations of the main fluoroquinolones
(p.o.)
Peak concentrations as a tool to determine acceptable
sensitivities to fluoroquinolones (p.o.)
Combining it all …(Peak and 24h-AUC / MIC) as predictors
of efficacy of FQ ...
Pharmacokinetics / Pharmacodynamics in action ...
Pharmacokinetics / Pharmacodynamics in action ...
Why would you not use low doses ?
Resistance: a global overview...
How do bacteria do it ?
PK/PD and antibiotic efflux pumps...
PK/PD and antibiotic efflux pumps… an example with
RND...
PK/PD for prevention of resistance: clinical data
PK/PD for prevention of resistance: clinical data
PK/PD for prevention of resistance: clinical data
PPT Slide
PK / PD: do they help ?
PK / PD: do they help ?
But we may, eventually have a brighter future... |