New cephalosporins … why ?
Resistance
- novel ?-lactamases (including inhibitor resistant types)
- efflux/permeability
- increasing resistance of Gram (+) bacteria in Community-Acquired Infections (MRSA)
Limitations in other existing, novel classes of drugs for resistant Gram (+) organisms
- fluoroquinolones vs MRSA and Enterococci
- streptogramins (tolerance / resistance)
- everninomycins (tolerance)