Can we dissociate toxicity and activity ?
Enhancement (%) of [3H]dizocilpine binding by apramycin ( ), 3-N-ethylapramycin ( ), and 2'-N-phthalimidoapramycin ( ). EC50 values are 3.4, 4.4 and 186 M for apramycin, 3-N-ethylapramycin, and 2'-N-phthalimidoapramycin, respectively
The antibacterial and NMDA receptor activating properties of aminoglycosided are dissociable
Scott C. Harvey, Xia Lia, Phil Skolnicka and Herbert A. Kirst
Lilly Research Laboratories, Neuroscience Discovery & Elanco Animal Health R&D