Can we make better aminoglycosides ?

The work of Paul J. Claes

R = - OH

- O- Alkyl

- O- Aryl

- X

- N(H,CH3, Bu) - CO(O) - Alkyl

- R- N- Alkyl

- R- S- Alkyl

- R - SO - Alkyl

- R - SO2 - Alkyl

Kanamycin B

Van Schepdael A, Delcourt J, Mulier M, Busson R, Verbist L, Vanderhaeghe HJ, Mingeot-Leclercq MP, Tulkens PM, Claes PJ. New derivatives of kanamycin B obtained by modifications and substitutions in position 6". 1. Synthesis and microbiological evaluation. J Med Chem. 1991 Apr;34(4):1468-75

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