PPT Slide

NH

2

COOH

?

ATP

ADP + Pi

tetracyclines

erythromycin

sulfadiazine

tetracyclines

fluoroquinolones

erythromycin

rifampicin

tetracyclines

fluoroquinolones

erythromycin

lincosamides

rifampicin

pristinamycin

tetracyclines

fluoroquinolones

macrolides

lincosamides

rifampicin

?-lactams

fluoroquinolones

fusidic acid

chloramphenicol

aminoglycosides

chloramphenicol

chloramphenicol

aminoglycosides

fluoroquinolones

tetracyclines

macrolides

+

+

+

+

+

+

SMR

RND

MFS

ABC

12 TMS

14 TMS

PgP

MRP

T

O

P

O

L

O

G

Y

M

E

C

H

A

N

I

S

M

A

N

T

I

B

I

O

T

I

C

S

Van Bambeke et al., 2000

aminoglycosides

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