Katholieke Universiteit Leuven 
Viering Prof. P.J. Claes:

Aminoglycosides and beta-lactams: from the work of Paul J. Claes to new recent developments

 

10/30/00

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Table of Contents

Katholieke Universiteit Leuven Viering Prof. P.J. Claes

Katholieke Universiteit Leuven Viering Prof. P.J. Claes

Katholieke Universiteit Leuven Viering Prof. P.J. Claes

Katholieke Universiteit Leuven Viering Prof. P.J. Claes

Aminoglycosides ...

Aminoglycosides ...

Aminoglycoside nephrotoxicity: understanding the molecular mechanism...

Aminoglycoside nephrotoxicity: understanding the molecular mechanism...

Aminoglycoside nephrotoxicity: towards the evaluation of new molecules...

Aminoglycoside nephrotoxicity: towards the evaluation of new molecules...

Aminoglycoside nephrotoxicity: demonstration of gentamicin-induced apoptosis ...

Aminoglycoside nephrotoxicity apoptosis occurs at low doses ...

Aminoglycoside nephrotoxicity : apoptosis severity varies among derivatives ...

Aminoglycosides also induce apoptosis in cultured cells ...

Promoting entry of aminoglycosides in bacteria ...

Self-promoted uptake of aminoglycosides ...

But there may be more than influx...

PPT Slide

Mechanisms of resistance

The AAP (3)-IIIa enzyme shows commonality with the eucaryotic protein kinase

The AAP(3)-IIIa interactions with aminoglycosides have been determined* 

Structure of AAP (3)-IIIa (Berghuis)

Structure of AAP (3)-IIIa (Berghuis)

Can we make better aminoglycosides ?

Can we map the aminoglycoside binding site to the ribosomal RNA ?

Building blocks for aminoglycoside chemistry ... 

Can we dissociate toxicity and activity ?

Maybe we can ...

?-lactams

?-lactam antiotics

?-lactam antiotics

?-lactam antiotics: new insights

New basic derivatives of lactams: why ?

Organic acids are driven out of cells ...

But weak organic bases are accumulated ...

A first basic derivative of penicillin G in the late 80s...

New basic derivatives of ?-lactams in the late 90s ...

New cephalosporins why ?

New cephalosporins how ?

New cephalosporins how ?

New cephalosporins how ?

New ?-lactamase inhibitors ?

new aminoglycosides, new ?-lactams, ...

helping to show the way ...

New medicines in Belgium in the 17th century...

Finding and showing the way ...

Besluit...

Besluit...

Danken ...

Author: Paul M. Tulkens 

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm