Table of Contents
Katholieke Universiteit Leuven Viering Prof. P.J.
Claes
Katholieke Universiteit Leuven Viering Prof. P.J.
Claes
Katholieke Universiteit Leuven Viering Prof. P.J.
Claes
Katholieke Universiteit Leuven Viering Prof. P.J.
Claes
Aminoglycosides ...
Aminoglycosides ...
Aminoglycoside nephrotoxicity: understanding the
molecular mechanism...
Aminoglycoside nephrotoxicity: understanding the
molecular mechanism...
Aminoglycoside nephrotoxicity: towards the evaluation
of new molecules...
Aminoglycoside nephrotoxicity: towards the evaluation
of new molecules...
Aminoglycoside nephrotoxicity: demonstration of
gentamicin-induced apoptosis ...
Aminoglycoside nephrotoxicity apoptosis occurs
at low doses ...
Aminoglycoside nephrotoxicity : apoptosis severity
varies among derivatives ...
Aminoglycosides also induce apoptosis in cultured
cells ...
Promoting entry of aminoglycosides in bacteria
...
Self-promoted uptake of aminoglycosides ...
But there may be more than influx...
PPT Slide
Mechanisms of resistance
The AAP (3’)-IIIa enzyme shows commonality with
the eucaryotic protein kinase
The AAP(3’)-IIIa interactions with aminoglycosides
have been determined*
Structure of AAP (3’)-IIIa (Berghuis)
Structure of AAP (3’)-IIIa (Berghuis)
Can we make better aminoglycosides ?
Can we map the aminoglycoside binding site to the
ribosomal RNA ?
Building blocks for aminoglycoside chemistry ...
Can we dissociate toxicity and activity ?
Maybe we can ...
?-lactams
?-lactam antiotics
?-lactam antiotics
?-lactam antiotics: new insights
New basic derivatives of lactams: why ?
Organic acids are driven out of cells ...
But weak organic bases are accumulated ...
A first basic derivative of penicillin G in the
late 80’s...
New basic derivatives of ?-lactams in the late
90’s ...
New cephalosporins … why ?
New cephalosporins … how ?
New cephalosporins … how ?
New cephalosporins … how ?
New ?-lactamase inhibitors ?
new aminoglycosides, new ?-lactams, ...
helping to show the way ...
New medicines in Belgium in the 17th century...
Finding and showing the way ...
Besluit...
Besluit...
Danken ... |