24h-AUC / MIC as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)

Drug Dosage 24h-AUC

(mg/24h) (mg/L x h)

norfloxacin 800 14 *, #

ciprofloxacin 500 12 *

ofloxacin 400 31 to 66 *, +

levofloxacin 500 47 *

gatifloxacin 400 35 *

moxifloxacin 400 48 *

* US prescrib. inf. (adult of 60 kg) of NOROXIN®, CIPRO®, FLOXIN®, LEVAQUIN®, TEQUIN®  and AVELOX®; # litterature data; + first dose to equilibrium

PK/PD Bkpt

[AUC/MIC = 125]

0.1

0.1

0.2 - 0.4

0.4

0.3

0.4

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