The ideal antibiotic ...
Will it always be ideal ?
Main causes of antibiotic failures... Adapted from Pechère J.C., 1988, 1993, 1998
Pharmacokinetics / pharmacodynamics as a step towards therapy...
Pharmacokinetics ...
Pharmacodynamics ...
Pharmacokinetics / Pharmacodynamics in drug development and evaluation of efficacy
PK/PD in drug develop-ment A view from FDA
Are PK/PD important for efficacy / toxicity ?
Pharmacokinetic/ Pharmacodynamics and antibiotic resistance...
Are PK / PD important in resistance ?
PK/PD parameters: a first sight
PK/PD parameters : a 2d sight
Pharmacokinetics / Pharmacodynamics
PK/PD patterns of antimicrobial activity (1 of 3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (2 of 3) (after WA. Craig, 2000)
PK/PD patterns of antimicrobial activity (3 of 3) (after WA. Craig, 2000)
Pharmacokinetics / Pharmacodynamics in action ...
Aminoglycosides : obtain a peak !
?-lactams : remain at least 50 % of the time above the MIC...
Typical pharmacokinetics of a model ?-lactam *
? - lactams * in clinical practice : influence of the schedule on potential breakpoint
Als u een optimale bescherming met ? lactamen wenst… Voorstel : continu-infusie (vb. 4 g / dag)
PK/PD of fluoroquinolones: role of the 24h-AUC MIC ciprofloxacin in hospital-acquired pneumonia
AUC / MIC ratio
PPT Slide
24h-AUC / MIC as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)
The role of the peak for fluoroquinolones ...
Peak concentrations as a tool to determine acceptable sensitivities to fluoroquinolones (p.o.)
Combining it all …(Peak and 24h-AUC / MIC) as predictors of efficacy of FQ ...
Pharmacokinetics / Pharmacodynamics in action: adusting the dose of a FQ for an MIC
Why would you not use low doses ?
Resistance: a global overview...
How do bacteria do it ?
PK/PD and antibiotic efflux pumps...
PK/PD and antibiotic efflux pumps… an example with RND...
PK / PD: do they help ?
and let us hope we have a bright future...
Email: tulkens@facm.ucl.ac.be
Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm