New derivatives of antibiotics with reduced affinity for transporters

ketolides versus macrolides

Macrolide MIC

susceptible strain resistant

strain by efflux

erythro 0.03 4

clarithro 0.0.3 4

roxithro 0.6 8

azithro 0.125 4

telithro 0.3 0.5

Melchior et al, AAC (2000) 44: 2999-3002