Probenecid - resistant macrophages [1 of 2]
- Several weeks of culture of wild-type J774 macrophages with increasing concentrations of probenecid ( 1 - 2 - 3 mM)
- Resistant clones (unfrequent)
supposed to overexpress efflux transporters for probenecid
Cao et al, 1993, Infect Agents Dis. 2:193-200