Evidencing active efflux : experimental strategy

2. Molecular characterization

• effect of inhibitors
  
  
  verapamil
  
  
  
  
  
  probenecid

OCH

3

H

3

CO

CN

CH(CH

3

)

2

NH

H

3

C

OCH3

OCH

3

+

COO

S

N

O

O

C

3

H

7

C

3

H

7

-

MDR

OCT

MRP

OAT

Inhibitor of

transporters for

CATIONS

Inhibitor of

transporters for

ANIONS

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