Combined action of drug transporters for drug elimination / absorption

urine

proximal tubular cell

Npt-1

PepT2

Oat1/3

Mrp2

Mct1

distal tubular cell

OctN2

Mrp1

blood

efflux / reuptake of b-lactams in kidney

cephaloridine

cephalexine

cephaloridine

cephalexine

carbenicilline

penicilline G

...

cloxacilline

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