Efflux and resistance in pathogenic bacteria

bacteria

efflux pump

super

family

b

-lactams

FA

AG

Tet

OX

ML

LM

CP

Rif

Q

SM

TM

penams

cephems

penems

mbact.

inhib

b-ase

NA

S.aureus

NorA

MFS

TetK-L

MFS

S. pneumoniae

mefE

MFS

pmrA

MFS

TetK-L

MFS

S. pyogenes

mefA

MFS

L.

monocytogenes

mdrL

MFS

M. tuberculosis

tap

MFS

TetK-L

MFS

LfrA

MFS

Enterococcus

mef?

MFS

TetK-L

MFS

H. influenzae

TetB, K

MFS

homl AcrAB

RND

N. gonorrheae

MtrCDE

RND

Salmonella

acrAB

RND

TetA-D

MFS

FloR

MFS

S. dysenteriae

TetA-D

MFS

E. coli

EmrE

SMR

SetA

MFS

EmrB

MFS

TetA-E

MFS

Bcr

MFS

MdfA

MFS

acrAB

RND

acrD

RND

S. maltophila

SmeDEF

RND

P. aeruginosa

CmlA

MFS

TetA,C,E

MFS

MexAB OprM

RND

MexCD OprJ

RND

MexEF OprN

RND

MexXY

RND

FQ

NO

YES

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