Do efflux pumps act as flippases ?

Functional evidences for MDR & MRP:

Translocation of phosphatidylcholine at the apical

(closed bars) and basolateral (open bars) membranes of MDR-3 (left) and MRP-1 (right) transfected LLC-PK1cells, in the absence of in the presence of inhibitors of the corresponding pump.

Smith et al,

J Biol Chem (2000) 275:23530-9

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