Antifungal drugs transporters : discovery
A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins. Nishi-K; Yoshida-M; Nishimura-M; Nishikawa-M; Nishiyama-M; Horinouchi-S; Beppu-T. Mol-Microbiol. 1992 Mar; 6(6): 761-9
Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Sanglard-D; Kuchler-K; Ischer-F; Pagani-JL; Monod-M; Bille-J. Antimicrob-Agents-Chemother. 1995 Nov; 39(11): 2378-8
Fluconazole-resistant C. albicans isolates failed to accumulate 3H-labelled fluconazole. This phenomenon was reversed in resistant cells by inhibiting the cellular energy supply with azide, suggesting that resistance could be mediated by energy-requiring efflux pumps such as those described as ATP-binding cassette (ABC) multidrug transporters.