Vancomycin /Teicoplanin PK/PD parameters taking into account protein binding

protein half 24h-AUC * MIC binding life total “free” ** max *

(%) (h) mg/L xh-1 mg/L

vancomycin 10- 50 % 6 400 ? 200 ? 1- 2(1g / 12h)

teicoplanin 90 > 40 560 ? 56 ? 0.5 (6 mg/kg in 24h)

* values directly proportional to the dose

** in vitro and animal PK/PD studies of most antibiotics show that only free drug is active

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