PPT Slide
2. European study (Vincks et al. 1999)
- 105 patients followed by active PK-guided monitoring (ATDM), vs
- 127 followed by non PK-guided monitoring (TDM)
- statistical improvements by ATDM vs TDM (pɘ.01):
- higher peaks (10.6 vs 7.6 mg/L)
- lower trough (0.7 vs 1.4 mg/L)
- shorter hospital stay (12.6 vs 18 days)
- lower incidence of nephrotoxicity (2.9 vs 13.4 %)
- lower total costs (NGL 8,883 vs 11,743)
Cost-effectiveness of antibiotic full PK monitoring: two examples with aminoglycosides (3 of 3)