PPT Slide
Cost-effectiveness of antibiotic full PK monitoring: two examples with aminoglycosides (1 of 3)
1. US studies (Crist et al 1987; Destache et al 1990)
- Two prospective, randomized studies with
- 75/118 adult patients with monitoring and full PK analysis ( = TDM/PK), vs
- 70/103 patients with isolated blood level determinations (no PK analysis; = control)
- homogenous groups in age, sex, size, pathogens, infected sites, Apache II score...