Mode of action : inhibition of bacterial cell wall synthesis upstream to ? lactams

CYTOPLASM

L-Ala

D-Ala

D-Ala:D-Ala ligase

D-Ala-D-Ala

NH2

L-Lys-D-Glu-L-Ala- -UDP

NH2

D-Ala-D-Ala-L-Lys-D-Glu-L-Ala- -UDP

NH2

D-Ala-D-Ala-L-Lys-D-Glu-L-Ala-

CELL WALL

-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

-L-Ala-D-Glu-L-Lys-D-Ala

NH

-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

transpeptidase

NH2

-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

transglycosylase

NH2

- L-Ala-D-Glu-L-Lys-D-Ala-D-Ala

? lactams

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