1st PK question : accumulation in cells ?

• ?-lactams ? 1x

• aminoglycosides ə to 2 x

• ansamycins 2-3 x

• tetracyclines 2-4 x

• fluoroquinolones 10-20 x

• macrolides 4 to > 100 x

But… accumulation is not necessarily sufficient

Previous slide

Next slide

Back to first slide

View graphic version