INTRACELLULAR ANTI-INFECTIVES: is it important for efficacy and do we need to care for toxicity ?
Which and Where are intracellular bacteria ?
These they are…
Here they are ...
Which PK/PD parameters to take in consideration ?
1st PK question : accumulation in cells ?
2d PK question : retention ?
3d PK question : subcellular localization ?
4th PK question : Re-distribution ?
1st PD question: expression of activity ?
2d PD question: bacterial responsiveness ?
3d PD question: cooperation host defenses ? (a) cell bactericidal mechanisms
3d PD question: cooperation host defenses ? (b) cytokines
PPT Slide
Which PK/PT parameters to take in consideration ?
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