From first to second generation of fluoroquinolones

1960

1970

1980

1990

2000

• Temafloxacin a

• Sparfloxacin b

• Grepafloxacin c

• Gatifloxacin d

• Gram (-);

• improved  Gram (+)

anti-anaerobe

a: Toyama, 1988 (?) ; b: Dainippon, 1985-1987; c: Otskuda, 1989; d: Kyorin, 1988

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