Continu-infuus van ? - lactamen in mucoviscidose : “phase I” studies (1)
Cystic fibrosis patients without clinical sign of infection
patient targeted loading infusion
no. serum level dose* rate**
1 32 mg/l 16 mg/kg 244 mg/h
2 32 mg/l 16 mg/kg 244 mg/h
* Dl = Vd x Css [ 0.50 l/kg x 32 mg/l ]
** Ko = Css x Cl [ 32 mg/l x (127 ml/min) x 60 ]