Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation
Over the last 10 years, a series of key concepts have emerged
- dose-effect relationships are not the same for all anti-infectives
- beta-lactames, glycopeptides vs aminoglycosides
- some anti-infectives are time dependent, others not
- subinhibitory effects, post-antibiotic effects, cooperation with host defenses modulate the activity of antiinfective drugs
- integration of pharmacodynamics/pharmacokinetics allows to fairly predict success or failure, and even emergence of resistance