Pharmacokinetics / Pharmacodynamics Fluoroquinolones: registering (or re-registering) with the correct dosage

Drug dosage peak AUC acceptable MIC mg µg/ml 24h (AUIC = 125)

trovafloxacin 200 2.3 25 0.2

300 iv 3.3 37.5 0.3

moxifloxacin 400 2.5 27 0.2

400 iv 4.6 36.9 0.3

ciprofloxacin 500 2x/d 2.5 42.5 0.3

* based on narmal half-lifes; doses for an adult of 60 kg

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