Pharmacokinetics / Pharmacodynamics Fluoroquinolones: finding an acceptable MIC

Drug Dosage AUC MIC for an

(mg/24h) AUIC = 125

norfloxacine 800 14 0.125

ciprofloxacine 400 17 0.125

ofloxacine 400 66 0.5

fleroxacine 400 170 1

péfloxacine 800 108 1

* based on narmal half-lifes; doses for an adult of 60 kg