Pharmacokinetics / Pharmacodynamics Aminoglycosides (for a 30 min infusion)

dosage practical peak (mg/L) peak / MIC ratio (mg/kg) si Vd = 0.25 for a MIC of

4 2 1 0.5

1 3 0.75 1.5 3 6

2 6 1.5 3 6 12

3 9 2.25 4.5 9 18

4 12 3 6 12 24

6 16 4 8 16 32

8 20 5 10 20 40

15 37 9 18 37 75