Pharmacokinetic/ Pharmacodynamics and Antiinfective Activity ...
- anti-infective drug usage has long been irrational or not based on sounds pharmacodynamics / toxicodynamics
- search for low doses for fear of toxicity
- “errors” in drug dosages at registration
- misunderstanding of what is an optimal schedule and what it implies
- pharmacokinetics has long beed used to establish “drug presence” rather than to make true correlations with efficacy
pharmacodynamics of antiinfective drugs was largely “terra ingognita” 10 years ago