Problems related with the discovery and use of new antibiotics
Problems related with the use of modern antibiotics (1 of 2)
Problems related with the use of modern antibiotics (2 of 2)
Resistance ...
Resistance...
Resistance: Production of AB-modifying enzymes
Resistance: aminoglycoside-modifying enzymes
Resistance: Why so many enzymes ?
Resistance: D-alanine & beta-lactame...
PPT Slide
Resistance: Why so many AB-degrading enzymes ?
Resistance: Efflux mechanisms
Resistance: other mechanisms...
Resistance: An overview...
Resistance: What to do ?...
Will efficacy prevent emergence of resistance ?
Pharmacokinetics / Pharmacodynamics Will efficacy prevent emergence of resistance ?
Are they parameters predicting a low rate of emergence of resistance ?
What is the concentration needed to prevent mutation and/or selection of bacteria with reduced susceptibility ?
2. Activity
Pharmacokinetic/ Pharmacodynamics and Antiinfective Activity ...
Pharmacokinetic/ Pharmacodynamics in Drug Development and Evaluation
Pharmacokinetics / Pharmacodynamics Aminoglycosides (for a 30 min infusion)
Aminoglycosides ...
Pharmacokinetics / Pharmacodynamics 2. beta-lactams (or how to remain > MIC)
Beta-lactams ...
Pharmacokinetics / Pharmacodynamics Fluoroquinolones: finding an acceptable MIC
Fuoroquinolones ...
Pharmacokinetics / Pharmacodynamics Fluoroquinolones: adusting the dose for an MIC
Pharmacokinetics / Pharmacodynamics Fluoroquinolones: registering (or re-registering) with the correct dosage
Time for a change ?
Yes, if we wish to really keep helping patients
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