Intracellular Infection: a Journey from Cell biology to the Design of New Chemotherapeutic Agents

Cincinnati, OH, October 8th, 1999

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Table of Contents

Intracellular Infection: a Journey from Cell biology to the Design of New Chemotherapeutic Agents

What is Intracellular Infection ?

These they are…

You need to consider (at least) the following questions:

1st question (and answer) : where do intracellular bacteria sojourn and thrive ? 

Antibiotics and Intracellular Bacteria : a Bit of Theory

2d question (and answer): which antibiotics do accumulate in cells ?

3d question (and answer) : where are intracellular antibiotics located ?

4th question: what are the antibiotic intracellular expressions of activity

5th question: what is the bacterial responsiveness to the antibiotics ?

6th question [1 of 2]: cooperation with the cell own defenses ?

6th question [2 of 2]: cooperation or antagonism with the actions of cytokines ?

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INTRACELLULAR INFECTION CYCLE OF Listeria monocytogenes hly+

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A few among many unanswered questions ...

Where published ? 

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Why do beta-lactams not accumulate in cells ? 

Why beta-lactams do not accumulate in cells ? 

Why beta-lactams do not accumulate in cells ? 

What if you are basic ? 

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New compounds...? 

Where published ? 

Thanks to the crew ... 

But where do they work ?

But, where is that ?

Author: Paul M. Tulkens 

Email: tulkens@facm.ucl.ac.be

Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm