Can we now define breakpoints for intracellular bacteria ?
simple approximations are possible (but would you accept not to use ampicillin and gentamicin for intracellular Listeria ?)
these approximations must be made more robust by designing more refined models (but in which ones would you put your money in ?)
in the meantime, conclusions from in vitro models must be confirmed by animal and clinical trials (would you try sparfloxacin in human listeriosis ?)