Pharmacokinetic/pharmacodynamic interactions: concepts,controversies and challenges Hamburg, Germany, May 10th, 1998
Can we define breakpoints for intracellular bacteria ?
Pharmacodynamic and pharmacokinetic parameters governing antibiotic activity against intracellular bacteria
Intracellular bacteria 1. where may they sojourn ?
Intracellular bacteria 2. which bacteria is (mainly) where ?
Pharmacodynamic and pharmacokinetic parameters 1. antibiotic penetration (a) how can they get there ?
Pharmacodynamic and pharmacokinetic parameters 1. antibiotic penetration (b) which ones ?
Pharmacodynamic and pharmacokinetic parameters 2. antibiotic efflux
Pharmacodynamic and pharmacokinetic parameters 3. antibiotic main localization
Pharmacodynamic and pharmacokinetic parameters 4. antibiotic accumulation
Pharmacodynamic and pharmacokinetic parameters 5. antibiotic expression of activity
Pharmacodynamic and pharmacokinetic parameters 6. bacterial responsiveness
Pharmacodynamic and pharmacokinetic parameters 7. cooperation with cell own defenses
Pharmacodynamic and pharmacokinetic parameters 8. cooperation with cytokines
Pharmacodynamic and pharmacokinetic parameters A story with Listeria...
INTRACELLULAR INFECTION CYCLE OF Listeria monocytogenes hly+
Concentration dependence of sparfloxacin (Sp), azithromycin (Azi) and ampicillin (Amp) activities against Listeria monocytogenes hly+ at pH 7.4
Concentration dependence of sparfloxacin (Sp), azithromycin (Azi) and ampicillin (Amp) activities against Listeria monocytogenes hly+ at pH 6.8
Influence of interferon-gamma on antibiotic accumulation
Influence of Interferon-gamma and L-MMA/catalase on intracellular growth of virulent (hly+) and non-virulent (hly-) L. monocytogenes and susceptibility to antibiotics
The intracellular travel of Listeria and antibiotics, cytokines, ROS and NOS...
Can we now define breakpoints for intracellular bacteria ?
Email: tulkens@facm.ucl.ac.be
Home Page: http://www.md.ucl.ac.be/facm/facm-conferences.htm