NEW FLUOROQUINOLONES PHARMACOKINETICS

TROVAFLOXACINa Ala-Tb GREPAFLOXACINc CIPROFLOXACINd (200 mg ) (600 mg) (500 mg)

Cmax (mg/L) 2-3 2.3 1.4 2.3

Tmax (h) 1 1 2 - 3 1.3

AUC (mg*h/L) 25 30 20 10

Vd (L/kg) 1.3 8 3

CSF:serum ratio 25%

T 1/2 (h) 10-12 12 10 -12 4

a Efthymiopoulos; J. Antimicrob. Chemother. 1997, 40, 35-43

b Vincent et al., J. Antimicrob. Chemother. 1997, 39, 75-80

c Teng et al., J. Antimicrob. Chemother. 1995, 36, 385-394

d Wise et al, J. Antimicrob. Chemother. 1986, 18, 71-82

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