NEW FLUOROQUINOLONES SIDE EFFECTS

TROVAFLOXACINa GREPAFLOXACINb,c CIPROFLOXACINd,e

gastro-intestinal

disorders 5-10 % 5-15 % 5 %

phototoxicity rare rare rare

headhaches 5 % 5 % < 1 %

convulsions - - -

dizziness 11 % 5 % < 1 %

drug interactions warfarine warfarine OK warfarine OK

theophylline OK theophylline theophylline

digoxin

a Haria & Lamb, Drugs 1997, 54, 435-445;

b Stahlmann & Schwabe, J. Antimicrob. Chemother. 1997, 40, 83-92; c Efthymiopoulos, J. Antimicrob.

Chemother. 1997, 40, 35-43;

d Schat et al Am. J. Med. 1989, 87, 98S-102S; e Brouwers, Drug. Saf. 1992, 7, 268-281

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