Two new fluoroquinolones soon in Belgium..

GREPAFLOXACIN

N

C

O

F

N

O

-

O

CH

3

HN

H

3

C

N

N

C

O

F

N

O

-

O

F

F

H

H

H

3

N

+

TROVAFLOXACIN

Brighty et al.

7-(3-azabicyclo[3.1.0]hexyl)quinolone antibacterial agents: synthesis and biological evaluation resulting in identification of CP-99,219.

33d ICAAC, 1993, New Orleans, LA, abstract 1509

Miyamoto et al.

Synthesis and biological properties of substituted 1,4-dihydro-5-methyl-4-oxo-3-quinolinecarboxylic acids.

Bioorg-Med-Chem. 1995 Dec; 3(12): 1699-706

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