1. Drug Discov Today. 2016 Jul;21(7):1114-29. doi: 10.1016/j.drudis.2016.04.001.
Epub 2016 Apr 16.

Modulating antibiotic activity towards respiratory bacterial pathogens by
co-medications: a multi-target approach.

Vandevelde NM(1), Tulkens PM(1), Van Bambeke F(2).

Author information: 
(1)Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute,
Université catholique de Louvain, Brussels, Belgium. (2)Pharmacologie cellulaire 
et moléculaire, Louvain Drug Research Institute, Université catholique de
Louvain, Brussels, Belgium. Electronic address:
francoise.vanbambeke@uclouvain.be.

Non-antibiotic drugs can modulate bacterial physiology and/or antibiotic
activity, opening perspectives for innovative therapeutic strategies. Focusing on
respiratory pathogens and considering in vitro, in vivo, and clinical data, here 
we examine the effect of these drugs on the expression of resistance mechanisms, 
biofilm formation, and intracellular survival, as well as their influence on the 
activity of antibiotics on bacteria. Beyond the description of the effects
observed, we also comment on concentrations that are active and discuss the
mechanisms of drug-drug or drug-target interactions. This discussion should be
helpful in defining useful targets for adjuvant therapy and establishing the
corresponding pharmacophores for further drug fine-tuning.

Copyright © 2016 Elsevier Ltd. All rights reserved.

PMID: 27094105  [PubMed - in process]