1: Curr Opin Drug Discov Devel. 2006 Mar;9(2):218-30. 

Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and

Van Bambeke F, Barcia-Macay M, Lemaire S, Tulkens PM.

Unite de Pharmacologie Cellulaire et Moleculaire, Universite Catholique de
Louvain, Brussels, Belgium. vanbambeke@facm.ucl.ac.be

The treatment of intracellular infections requires the use of antibiotics
presenting appropriate cellular pharmacokinetic and pharmacodynamic properties.
These properties, however, cannot be predicted on the simple basis of cellular
drug accumulation and minimum inhibitory concentration in broth. In most cases,
intracellular activity is actually lower than extracellular activity, despite
the fact that all antibiotics reach intracellular concentrations that are at
least equal to, and more often higher than the extracellular concentrations.
This discrepancy may result from impairment of the expression of antibiotic
activity or a change in bacterial responsiveness inside the cells. It therefore
appears important to evaluate the intracellular activity of antibiotics in
appropriate models.

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PMID: 16566292 [PubMed - indexed for MEDLINE]