1: Apoptosis. 2008 Jan;13(1):11-32.

Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular
mechanisms and potential approaches to modulation.

Servais H, Ortiz A, Devuyst O, Denamur S, Tulkens PM, Mingeot-Leclercq MP.

Faculty of Medicine, Unité de Pharmacologie Cellulaire et Moléculaire, Université
Catholique de Louvain, UCL 7370 Avenue E. Mounier 73, Brussels, 1200, Belgium,

Apoptosis plays a central role not only in the physiological processes of kidney 
growth and remodeling, but also in various human renal diseases and drug-induced 
nephrotoxicity. We present in a synthetic fashion the main molecular and cellular
pathways leading to drug-induced apoptosis in kidney and the mechanisms
regulating it. We illustrate them using three main nephrotoxic drugs (cisplatin, 
gentamicin, and cyclosporine A). We discuss the main regulators and effectors
that have emerged as key targets for the design of therapeutic strategies. Novel 
approaches using gene therapy, antisense strategies, recombinant proteins, or
compounds obtained from both classical organic and combinatorial chemistry are
examined. Finally, key issues that need to be addressed for the success of
apoptosis-based therapies are underlined.

PMID: 17968659 [PubMed - in process]

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