1: Antimicrob Agents Chemother  2001 Sep;45(9):2643-7

Stability and compatibility of ceftazidime administered by continuous infusion
to intensive care patients.

Servais H, Tulkens PM.

Unite de Pharmacologie Cellulaire et Moleculaire, Universite catholique de
Louvain, Brussels, Belgium. Helene.Servais@facm.ucl.ac.be

The stability and compatibility of ceftazidime have been examined in the context
of its potential use in concentrated solutions for continuous infusion in
patients suffering from severe nosocomial pneumonia and receiving other
intravenous medications by the same route. Ceftazidime stability in 4 to 12%
solutions was found satisfactory (<10% degradation) for 24 h if kept at a
temperature of 25 degrees C (77 degrees F) maximum. Studies mimicking the
simultaneous administration of ceftazidime and other drugs as done in clinics
showed physical incompatibilities with vancomycin, nicardipine, midazolam, and
propofol and a chemical incompatibility with N-acetylcystein. Concentrated
solutions (50 mg/ml) of erythromycin or clarithromycin caused the appearance of
a precipitate, whereas gentamicin, tobramycin, amikacin, isepamicin,
fluconazole, ketamine, sufentanil, valproic acid, furosemide, uradipil, and a
standard amino acid solution were physically and chemically compatible.

PMID: 11502544 [PubMed - indexed for MEDLINE]